QuickBooks Error 15270 typically occurs during payroll updates, indicating that the update was incomplete due to a missing file or incorrect setup. To resolve this issue, follow these steps:

1. Verify Payroll Subscription: Ensure your payroll subscription is active. Go to "Employees" > "My Payroll Service" > "Account/Billing Information" to check your subscription status.

2. Update QuickBooks to the Latest Release: Keeping QuickBooks updated helps prevent errors. Go to "Help" > "Update QuickBooks Desktop" and download any available updates.

3. Restart QuickBooks Desktop: Close QuickBooks completely and reopen it. This can clear minor glitches that might be causing the error.

4. Run QuickBooks as Administrator: Right-click on the QuickBooks icon and select "Run as Administrator." This gives the program full access to make necessary changes.

5. Reset the Payroll Update: Go to "Employees" > "Get Payroll Updates" and check the box for "Download entire payroll update again." Click "Update" to reinstall the payroll update.

6. Check Internet Connection: Ensure your internet connection is stable, as a weak connection can cause incomplete updates.

7. Temporarily Disable Security Software: Sometimes, antivirus or firewall settings can block updates. Temporarily disable your security software and try the update again.

If the error persists, consider contacting QuickBooks support for further assistance.